产品基本信息

产品名称：胆酸示踪探针CLF

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：926.12

外观：黄色固体

溶剂：DMSO

激发波长(nm)：498

发射波长(nm)：517

产品介绍

CLF是荧光素标记的胆汁酸类似物，与胆酸衍生物的细胞结合和吸收特性密切相关。它是一种二价的“单极性”阴离子荧光单羟基胆盐类似物，具有与石胆酸类似的物理、生物和胆汁抑制特性，肝胆酸及其衍生物为研究单羟基胆盐致肝细胞胆汁淤积的机制提供了一个有用的途径。CLF目前被用作肝组织内胆汁酸转运的工具。金畔生物是AAT Bioquest的中国代理商，为您提供优质的胆酸示踪探针CLF。

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参考文献

Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs
Authors: Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, Sugiyama Y.
Journal: Drug Metab Dispos (2006): 1575

Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A
Authors: Perez LM, Milkiewicz P, Elias E, Coleman R, Sanchez Pozzi EJ, Roma MG.
Journal: Toxicol Sci (2006): 150

Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes
Authors: Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL.
Journal: Gastroenterology (2006): 878

Small hepatocytes in culture develop polarized transporter expression and differentiation
Authors: Sidler Pf and ler MA, Hochli M, Inderbitzin D, Meier PJ, Stieger B.
Journal: J Cell Sci (2004): 4077

Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets
Authors: Roman ID, Fern and ez-Moreno MD, Fueyo JA, Roma MG, Coleman R.
Journal: Toxicol Sci (2003): 276

Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
Authors: Beuers U, Denk GU, Soroka CJ, Wimmer R, Rust C, Paumgartner G, Boyer JL.
Journal: J Biol Chem (2003): 17810

Vectorial transport of bile acids in immortalized mouse bile duct cells
Authors: Kida M, Mano Y, Ueno Y, Kobayashi K, Goto J, Ishii M, Shimosegawa T.
Journal: Hepatol Res (2003): 151

Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways
Authors: Milkiewicz P, Roma MG, Elias E, Coleman R.
Journal: Gut (2002): 113

Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets
Authors: Crocenzi FA, Sanchez Pozzi EJ, Pellegrino JM, Favre CO, Rodriguez Garay EA, Mottino AD, Coleman R, Roma MG.
Journal: Hepatology (2001): 329

Use of a fluorescent bile acid to enhance visualization of the biliary tract and bile leaks during laparoscopic surgery in rabbits
Authors: Holzinger F, Krahenbuhl L, Schteingart CD, Ton-Nu HT, Hofmann AF.
Journal: Surg Endosc (2001): 209