产品基本信息

产品名称：放线菌素 D

CAS：50-76-0

储存条件：保存在冰箱-15℃干燥

保质期：12个月

产品物理化学光谱特性

分子量：1255.42

溶剂：DMSO

产品介绍

放线菌素是从链霉菌属的土壤中分离的多肽。它与DNA双链体结合，从而干扰参与复制和转录的酶的作用。放线菌素D是已用于多年的旧化疗之一。放线菌素D也用作抗性的选择性，通常浓度为约1μg/ ml。该产品以粉末形式提供，应制成DMSO中1mg / ml的储备溶液。

参考文献

A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of actinomycin-D and vincristine in children with cancer
Authors: Skolnik JM, Barrett JS, Shi H, Adamson PC.
Journal: Cancer Chemother Pharmacol (2006): 458

Anti-apoptotic effect of hepatocyte growth factor from actinomycin D in hepatocyte-derived HL7702 cells is associated with activation of PI3K/Akt signaling
Authors: Li W, Cai S, Cai L, Li X.
Journal: Toxicol Lett (2006): 142

Binding of actinomycin C1 (D) and actinomin to base-modified oligonucleotide duplexes with parallel chain orientation
Authors: Li H, Peng X, Leonard P, Seela F.
Journal: Bioorg Med Chem (2006): 4089

Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway
Authors: Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS.
Journal: Biochem Biophys Res Commun (2006): 1172

Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X2-producer
Authors: Kurosawa K, Bui VP, VanEssendelft JL, Willis LB, Lessard PA, Ghiviriga I, Sambandan TG, Rha CK, Sinskey AJ.
Journal: Appl Microbiol Biotechnol (2006): 145

Dexamethasone, melphalan, actinomycin D, cytosine arabinoside (DMAC) protocol for dogs with relapsed lymphoma
Authors: Alvarez FJ, Kisseberth WC, Gallant SL, Couto CG.
Journal: J Vet Intern Med (2006): 1178

Downregulation of inhibitor of apoptosis proteins in apoptotic human chondrocytes treated with tumor necrosis factor-alpha and actinomycin D
Authors: Yoshimura F, Kanno H, Uzuki M, Tajima K, Shimamura T, Sawai T.
Journal: Osteoarthritis Cartilage (2006): 435

Evaluation of an actinomycin-D-containing combination chemotherapy protocol with extended maintenance therapy for canine lymphoma
Authors: Siedlecki CT, Kass PH, Jakubiak MJ, Dank G, Lyons J, Kent MS.
Journal: Can Vet J (2006): 52

Expression of cell kinetics and death during monocyte-macrophage differentiation: effects of Actinomycin D and Vinblastine treatments
Authors: Spano A, Monaco G, Barni S, Sciola L.
Journal: Histochem Cell Biol. (2006)

Fluorescent intercalator displacement analyses of DNA binding by the peptide-derived natural products netropsin, actinomycin, and bleomycin
Authors: Lewis MA, Long EC.
Journal: Bioorg Med Chem (2006): 3481