产品基本信息

产品名称：唑酮基磷酸胆碱

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：378.32

溶剂：水

激发波长(nm)：575

发射波长(nm)：590

产品介绍

磷酸基团绿色荧光底物 PhosLite 是美国AAT Bioquest生产的用于磷酸胆碱的染料，甘油磷酸二酯酶可以催化磷酸胆碱从试卤灵磷酸胆碱中释放，并产生高荧光强度的试卤灵，该过程可以使用荧光法和比色吸收法来检测。这种磷酸二酯酶荧光底物能方便用于筛选甘油磷酸二酯酶的抑制剂。它可以用来检测磷脂酶D结合磷酸酶的活性。磷脂酶水解试卤灵磷酸胆碱并产生试卤灵磷酸盐，然后在酸性磷酸酶作用下，生成试卤灵。因此，试卤灵磷酸胆碱也可以用来检测那些不含高水平磷脂酶C的样本内磷脂酶D。金畔生物是AAT Bioquest的中国代理商，为您提供优质的唑酮基磷酸胆碱。 

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参考文献

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
Authors: Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A.
Journal: Mol Cancer Ther (2009): 240

Antiplatelet cilostazol, an inhibitor of type III phosphodiesterase, improves swallowing function in patients with a history of stroke
Authors: Teramoto S, Yamamoto H, Yamaguchi Y, Ishii M, Hibi S, Kume H, Ouchi Y.
Journal: J Am Geriatr Soc (2008): 1153

Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
Authors: Dell’Agli M, Maschi O, Galli GV, Fagnani R, Dal Cero E, Caruso D, Bosisio E.
Journal: Br J Nutr (2008): 945

Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE)
Authors: Dallas C, Gerbi A, Tenca G, Juchaux F, Bernard FX.
Journal: Phytomedicine (2008): 783

The effects of a type 4 phosphodiesterase inhibitor and the muscarinic cholinergic antagonist tolterodine tartrate on detrusor overactivity in female rats with bladder outlet obstruction
Authors: Kaiho Y, Nishiguchi J, Kwon DD, Chancellor MB, Arai Y, Snyder PB, Yoshimura N.
Journal: BJU Int (2008): 615

Biochemical characterization of ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat heart left ventricle
Authors: Rucker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ.
Journal: Mol Cell Biochem (2007): 247

Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX
Authors: Ghanem E, Li Y, Xu C, Raushel FM.
Journal: Biochemistry (2007): 9032

Characterization of the 2′,3′ cyclic phosphodiesterase activities of Clostridium cellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase
Authors: Keppetipola N, Shuman S.
Journal: Nucleic Acids Res (2007): 7721

Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs
Authors: Fujimura M, Liu Q.
Journal: Pulm Pharmacol Ther (2007): 543

Cilostazol, an inhibitor of type 3 phosphodiesterase, produces endothelium-independent vasodilation in pressurized rabbit cerebral penetrating arterioles
Authors: Nakamura K, Ikomi F, Ohhashi T.
Journal: J Vasc Res (2006): 86