产品基本信息

产品名称：硫代黄素T,羧酸

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：496.55

溶剂：DMSO

激发波长(nm)：349

发射波长(nm)：454

产品介绍

硫黄素T（ThT），也称为碱性黄1或CI 49005，是苯并噻唑盐。 该染料用于可视化由阿尔茨海默氏病患者的大脑中发现的β-淀粉样蛋白组成的斑块。 当它与β片层结合时，例如淀粉样蛋白低聚物中的那些，该染料的激发光谱发生特征性的120nm红移，可以在450nm处选择性激发，从而产生482nm的荧光信号。 ThT快速且特异性地与合成β-淀粉样蛋白（1-40）形成的反平行β-折叠原纤维结合，但不与单体或低聚中间体结合。 ThT的结合不会干扰β淀粉样肽向淀粉样原纤维的聚集。 硫黄素T酸是制备硫黄素T的各种生物缀合物的有用工具，所述生物缀合物可以将硫黄素T导向所需的靶标。 它是制造硫黄素T的肽和其他缀合物的重要试剂。金畔生物是AAT Bioquest的中国代理商，为您提供优质的硫代黄素T,羧酸。 

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参考文献

Fluorescent dyes in the context of DNA-binding: The case of Thioflavin T
Authors: Biancardi, Aless and ro and Biver, Tarita and Mennucci, Benedetta
Journal: International Journal of Quantum Chemistry (2017)

Human Telomeric Hybrid-2-over-Hybrid-1 G-quadruplex Targeting and a Selective Hypersaline-Tolerant Sensor Using Abasic Site-Engineered Monomorphism
Authors: Wu, Tao and Ye, Meiyun and Mao, Tianyi and Lin, Fan and Hu, Yuehua and Gan, Ning and Shao, Yong
Journal: Analytica Chimica Acta (2017)

Determinants of amyloid fibril degradation by the PDZ protease HTRA1
Authors: Poepsel, Simon and Sprengel, Andreas and Sacca, Barbara and Kaschani, Farnusch and Kaiser, Markus and Gatsogiannis, Christos and Raunser, Stefan and Clausen, Tim and Ehrmann, Michael
Journal: Nature chemical biology (2015): 862–869

Thioflavin T as a fluorescence probe for monitoring RNA metabolism at molecular and cellular levels
Authors: Sugimoto, Shinya and Arita-Morioka, Ken-ichi and Mizunoe, Yoshimitsu and Yamanaka, Kunitoshi and Ogura, Teru
Journal: Nucleic acids research (2015): gkv338

Ag nanoclusters as probes for turn-on fluorescence recognition of TpG dinucleotide with a high selectivity
Authors: Peng, Jian and Shao, Yong and Liu, Lingling and Zhang, Lihua and Liu, Hua and Wang, Ying
Journal: Analytica chimica acta (2014): 78–84

Mechanistic aspects of thioflavin-T self-aggregation and DNA binding: evidence for dimer attack on DNA grooves
Authors: Biancardi, A and Biver, T and Burgalassi, A and Mattonai, M and Secco, F and Venturini, M
Journal: Physical Chemistry Chemical Physics (2014): 20061–20072

Molecular rotor-based fluorescent probe for selective recognition of hybrid G-quadruplex and as a K+ sensor
Authors: Liu, Lingling and Shao, Yong and Peng, Jian and Huang, Chaobiao and Liu, Hua and Zhang, Lihua
Journal: Analytical chemistry (2014): 1622–1631

Selective recognition of ds-DNA cavities by a molecular rotor: switched fluorescence of thioflavin T
Authors: Liu, Lingling and Shao, Yong and Peng, Jian and Liu, Hua and Zhang, Lihua
Journal: Molecular BioSystems (2013): 2512–2519

Characteristics of the binding of thioflavin S to tau paired helical filaments
Authors: Santa-Maria I, Perez M, Hern and ez F, Avila J, Moreno FJ.
Journal: J Alzheimers Dis (2006): 279

Lipophilic analogs of thioflavin S as novel amyloid-imaging agents
Authors: Wu C, Cai L, Wei J, Pike VW, Wang Y.
Journal: Curr Alzheimer Res (2006): 259