产品基本信息

产品名称：锌离子荧光探针Zinquin 

CAS：151606-29-0

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：386.42

外观：淡黄色固体

溶剂：DMSO

激发波长（nm）：355

发射波长（nm）：491

产品介绍

锌离子荧光探针Zinquin 是美国AAT Bioquest生产的用于检测锌离子的荧光探针。Zinquin是一种锌敏感的，细胞不可渗透的荧光探针。锌是人体中第二丰富的过渡金属，它是催化，结构和调节离子必不可少的元素。锌离子参与体内平衡，免疫反应，氧化应激，细胞凋亡和衰老。已经提出锌起突触前神经元的常规神经递质的作用，并作为横穿突触后神经元的跨膜信号。锌代谢异常与许多神经系统疾病有关，包括阿尔茨海默氏病，帕金森氏病和癫痫病。已经证明用于体内锌监测的最合适技术是荧光成像。金畔生物是AAT Bioquest的中国代理商，为您提供优质的锌离子荧光探针Zinquin 。 

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参考文献

Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment
Authors: Colvin RA, Laskowski M, Fontaine CP.
Journal: Brain Res (2006): 1

S-Nitroso compounds interfere with zinc probing by Zinquin
Authors: Jansen S, Arning J, Dulcks T, Beyersmann D.
Journal: Anal Biochem (2004): 145

Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes
Authors: Hendrickson KM, Geue JP, Wyness O, Lincoln SF, Ward AD.
Journal: J Am Chem Soc (2003): 3889

Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments
Authors: Snitsarev V, Budde T, Stricker TP, Cox JM, Krupa DJ, Geng L, Kay AR.
Journal: Biophys J (2001): 1538

The synthesis and fluorescent properties of analogues of the zinc(II) specific fluorophore zinquin ester
Authors: Kimber MC, Mahadevan IB, Lincoln SF, Ward AD, Tiekink ER.
Journal: J Org Chem (2000): 8204

Changes in distribution of labile zinc in mouse spermatozoa during maturation in the epididymis assessed by the fluorophore Zinquin
Authors: Zalewski PD, Jian X, Soon LL, Breed WG, Seamark RF, Lincoln SF, Ward AD, Sun FZ.
Journal: Reprod Fertil Dev (1996): 1097

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin
Authors: Zalewski PD, Forbes IJ, Seamark RF, Borlinghaus R, Betts WH, Lincoln SF, Ward AD.
Journal: Chem Biol (1994): 153

Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc
Authors: Coyle P, Zalewski PD, Philcox JC, Forbes IJ, Ward AD, Lincoln SF, Mahadevan I, Rofe AM.
Journal: Biochem J (1994): 781