产品基本信息

产品名称：MMP Green 基质金属蛋白酶绿色荧光底物

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：~2000

溶剂：DMSO

激发波长(nm)：498

发射波长(nm)：520

产品介绍

MMP Green 基质金属蛋白酶绿色荧光底物是美国AAT Bioquest生产的用于检测MMP的试剂盒，基质金属蛋白酶(MMPs)组成了锌依赖的内肽酶家族，它们是细胞外基质中发挥重要的作用。这些酶造成结缔组织的断裂，并且在骨骼重塑、月经周期和坏损组织的修复中发挥着重要作用。目前，对MMPs在生理功能中的具体作用还难以评定，但是也发现其在关节炎的形成，癌症的浸入和转移中发挥关键作用。MMPs具有多种底物，这些家族成员中的大部分成员都可以降解不同类型的胶原蛋白，这些胶原蛋白通常与弹力素，凝胶和纤粘蛋白一起。很难找到一种选择性的单一MMP酶底物。该试剂盒内的FRET底物是是用于检测一种MMP酶活性的底物，也可结合纯化的MMP蛋白，被用于MMP酶抑制剂的筛选。该FRET底物是基于AAT Bioquest的TF2/TQ2 FRET对，当MMP催化水解其底物时，TF2/TQ2 FRET对分离，这样FRET多肽底物MMP Green的荧光强度增加，相应的其荧光强度与MMP酶活性成比率，以获得其活性数值。金畔生物是AAT Bioquest的中国代理商，为您提供优质的MMP Green 基质金属蛋白酶绿色荧光底物。 

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参考文献

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