产品基本信息

产品名称：线粒体膜电位荧光探针10-壬基吖啶橙溴化物

CAS：75168-11-5

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：472.5

溶剂：DMSO

激发波长（nm）：495

发射波长（nm）：519

产品介绍

线粒体膜电位荧光探针10-壬基吖啶橙溴化物是美国AAT Bioquest生产的细胞膜电位荧光探针。10-壬基吖啶橙(NAO)是吖啶橙的衍生物, 是一种用于完整细胞内线粒体特异性荧光标记物。与Rh123相比，细胞中NAO的积聚与质子动力驱动关系不大，但是与线粒体相关膜蛋白或者脂类发生作用相关。NAO的摄入不依赖于线粒体跨膜电势差，可用于检测线粒体。NAO可与心磷脂等带负电荷磷脂特异性结合, 其与线粒体膜的相互作用不依赖于线粒体的膜电位; 分析细胞凋亡时, 可用罗丹明123来检测线粒体的膜电位, 而用NAO来检测线粒体结构的完整性。NAO和罗丹明123（Rh123）是研究线粒体功能一对好的染料。金畔生物是AAT Bioquest的中国代理商，为您提供优质的线粒体膜电位荧光探针10-壬基吖啶橙溴化物。 

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参考文献

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Binding of 10-N-nonyl acridine orange to cardiolipin-deficient yeast cells: implications for assay of cardiolipin
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Determination of dipole moment in the ground and excited state by experimental and theoretical methods of N-nonyl acridine orange
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Journal: Spectrochim Acta A Mol Biomol Spectrosc (2005): 1172

Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different experimental models
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Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass
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Journal: J Neurochem (2002): 224

Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces
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Visualization of phospholipid domains in Escherichia coli by using the cardiolipin-specific fluorescent dye 10-N-nonyl acridine orange
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Journal: J Bacteriol (2000): 1172

Direct cardiolipin assay in yeast using the red fluorescence emission of 10-N-nonyl acridine orange
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Journal: Eur J Biochem (1995): 113

10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria
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Journal: Eur J Biochem (1992): 267