产品基本信息

产品名称：细胞膜荧光探针BTA-1

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：240.32

溶剂：DMSO

激发波长(nm)：349

发射波长(nm)：421

产品介绍

BTA-1是一种荧光性硫黄素-T衍生物，对淀粉样沉积物具有高亲和力（对于Ab 40，Ki = 11 nM）。 它穿过血脑屏障，表现出比硫黄素-T高50倍的亲和力，并用于对PS1 / APP转基因小鼠的大脑中的斑块和脑血管淀粉样蛋白沉积物进行选择性染色。金畔生物是AAT Bioquest的中国代理商，为您提供优质的细胞膜荧光探针BTA-1。 

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参考文献

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Journal: Appl Radiat Isot (2005): 591

Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937

Multiple ligand binding sites on A beta(1-40) fibrils
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5

Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies
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Journal: J Gen Virol (2004): 1785

Development of a PET/SPECT agent for amyloid imaging in Alzheimer’s disease
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55

In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
Authors: Verhoeff NP, Wilson AA, Takeshita S, Trop L, Hussey D, Singh K, Kung HF, Kung MP, Houle S.
Journal: Am J Geriatr Psychiatry (2004): 584

The binding of 2-(4′-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
Authors: Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA.
Journal: J Neurosci (2003): 2086